What Is Sotos Syndrome?
3. Central Nervous System
Patients with Sotos syndrome often have central nervous system symptoms. There is often delay in achieving milestones, speech, talking, and walking. Clumsiness is also present in 60% to 80% of affected children perhaps due to lax joints and low muscle tone.
They may not be able to walk until 15 to 17 months of age. Other physical challenges include difficulty with coordination (bicycle riding or sports), and fine motor skills (issues with grasping small stuff). Language can also be affected and they may not be able to speak until 2 to 3 years old. In 80% to 85% of patients, there is intellectual disability with an average intelligence quotient (IQ) of 72, which can range from 40 to mild intellectual disability. It is estimated that about 15% to 20% have normal intelligence.
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