Sotos syndrome is a condition first described in 1964. It is a condition where the affected individual experiences excessive physical growth throughout their first few years in life. It is a genetic condition causing excessive growth in infancy that continues into the early teenage years.
It is estimated to occur in approximately 1 in every 14,000 births. However, because the features of Sotos syndrome is often similar to other conditions, some experts believe that many cases of Sotos syndrome are not properly diagnosed. They believe that the true incidence of Sotos syndrome is more likely to be 1 in every 5,000 births.
1. Excessive Growth
The main issue in Sotos syndrome is the excessive growth. Even in the fetal period, there is prenatal overgrowth. After birth, the growth velocity of patients with Sotos syndrome is excessive, especially in the first 3 to 4 years of life. It then proceeds at a normal rate despite being in the high percentile. During childhood, the affected child tends to have a height that is 2 to 3 years ahead of their peers. Their weight will be appropriate for their age. Their bone age will show that it is ahead by 2 to 4 years of their chronological age. Their adult height will also usually exceed the average height of their peers. In male patients, they can reach a height of 193 cm (6”4) to 203 cm (6”8) while females reach up to 188 cm (6”2).