Ibuprofen Side Effect #2: Heartburn and Stomach Pain
Heartburn is a gastroesophageal reflux disease (GERD) symptom caused by digestive juice refluxing up the esophagus. When this mixture of digestive juice and food gets up the esophagus due to the esophagus sphincter opening, a burning sensation is experienced. Additionally, heartburn (burning sensation) can happen within the stomach in cases where digestive juices start to burn your stomach lining.
When you take ibuprofen (or other NSAID pill) in excess, it blocks the production of chemicals that protect the stomach lining from digestive juice corrosion. Such effects lead to severe stomach pains.