10 Causes of Orthostatic Hypotension
Reviewed: Dr. Gromatzky
Cause #9: Medications
Orthostatic hypotension has been observed as a side effect of certain medications such as antidepressants like tricyclics and monoamine oxidase inhibitors particularly in older adults. It can also be caused by alpha-1 blockers as it causes inhibition of vasoconstriction, which is usually performed by the baroreceptor reflex causing a decrease in pressure.
Other examples include hypertensives, which impair the autonomic reflex mechanisms, and diuretics, due to reduced intravascular volume.
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