What Is Pancreatitis?

2. Pathogenesis of Pancreatitis

Acute pancreatitis is thought to occur when the factors maintaining cellular homeostasis are imbalanced. It may be precipitated by events that damage the acinar cell or affect the zymogen granule secretion. This can be seen as a side effect of certain drugs, alcohol use, and gallstones. Despite being unclear regarding the exact cause of acute pancreatitis, experts believed that it could be caused by both intracellular and extracellular factors. In chronic pancreatitis, there is fibrogenesis in the pancreas due to a response to injury. This is thought to be due to cytokines, chemokines, and growth factors resulting in fibroblast proliferation and extracellular matrix deposition.

What Is Pancreatitis?

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