What Causes an Enlarged Spleen?
Reviewed: Dr. Gromatzky
2. Causes of an Enlarged Spleen
Many diseases and conditions can lead to splenomegaly. The most common cause of enlarged spleen is a viral infection called mononucleosis. Liver problems such as liver cirrhosis, cystic fibrosis, and chronic liver failure can also lead to an enlarged spleen.
In addition, juvenile rheumatoid arthritis is associated with many organ problems including enlarged spleen, since it leads to inflammation of the lymph system, which includes the spleen.
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