10 Smallpox Symptoms
Reviewed: Dr. Mera
Symptom #5: Malaise
Malaise refers to the general feeling of discomfort, pain, or uneasiness. This symptom is one of the first indications of disease or infection. It is a non-specific symptom that can be seen in various conditions such as hunger, cancer, heart attack, stroke, viral infections, bacterial infections, and parasitic infections.
Experts believe that malaise occurs due to the activation of an immune response where pro-inflammatory cytokines are released.
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