10 Smallpox Symptoms
Reviewed: Dr. Mera
Symptom #4: Skin Rash
The skin rash in smallpox is very characteristic. The lesions can be seen on the face, extremities, trunk, palms, and soles with a centrifugal pattern of distribution. These lesions will develop uniformly as the disease progresses from macules to papules and papules to vesicles over a duration of four to five days.
The vesicles will umbilicate and evolve to form pustules that are tense, round, firm, and deep-seated in the skin. These lesions will then crust and form scabs that eventually slough off fourteen days after the onset of rash.
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