10 Neurofibromatosis Symptoms
Reviewed: Dr. Mera
Symptom #7: Lisch Nodules
Lisch nodules or iris hamartoma refers to a pigmented malformation in the iris portion of the eye. They are usually benign. This aggregate of melanocytes is named after the Austrian ophthalmologist Karl Lisch who discovered them in 1937. Lisch nodules are usually found in patients with neurofibromatosis type 1. As many as 94% of neurofibromatosis type 1 patients over the age of 6 have Lisch nodules.
These nodules are described to be clear yellowish-brown papules that can be oval, round, or dome-shaped. Lisch nodules project from the surface of the iris. While it does not affect vision, it is very helpful in the diagnosis of neurofibromatosis type 1.
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