10 Symptoms of Marfan Syndrome
Reviewed: Dr. Gromatzky
Symptom #6: Partial Lens Dislocation (Subluxation)
Patients with Marfan syndrome can experience issues with their eyes. One of the main issues is partial lens dislocation where the lens of the affected eye shifts out of the normal position. Partial lens dislocation occurs as there is weakness in the ciliary zonules (also known as the suspensory ligaments of the lens, which is a ring of fibrous strands that connects the ciliary body to the lens of the eye).
The mutations in Marfan syndrome causes the stretching of the ciliary zonules. The subluxation can be detected in 80% of patients using a slit-lamp biomicroscope or imaging with high resolution ultrasound. Other issues with the eyes include strabismus, esotropia, exotropia, and corneal flatness.
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