10 Low Cortisol Symptoms
Symptom #7: Skin Issues
One of the main characteristics among individuals with low cortisol levels would be hyperpigmentation of the mucous membranes and skin. This is due to the stimulant effect of excessive adrenocorticotrophic hormone (ACTH) that binds to the melanocortin 1 receptor to produce melanin.
While hyperpigmentation is typically generalized, it is usually most prominent on the sun-exposed areas such as knees, elbows, knuckles, extensor surfaces, and scars. Other areas that may be affected include the nail beds, palmar creases, mucous membranes of the oral cavity, perianal, and vaginal mucosa. Other skin issues that may occur among those with low cortisol levels include vitiligo, where white patches appear on different parts of the body.
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