What Is Cholestasis?
3. What Is Intrahepatic Versus Extrahepatic Cholestasis?
Intrahepatic cholestasis is a term used when the condition is caused by a source inside the liver. Obstetric cholestasis fits within this overarching category. Certain diseases or infections, such as HIV, sickle cell, hepatitis, or lymphomas can lead to intrahepatic cholestasis. It can also be a result of certain medications or drug and alcohol use.
On the other hand, extrahepatic cholestasis signifies an external source is to blame. Often, this is due to a blockage of one of the bile ducts or a part of the digestive system that bile needs to flow through to meet with the bilirubin and exit the body. Gallstones or bile duct stones can form due to issues with the gallbladder or excess cholesterol. Tumors can also cause blockages.
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