What Causes Prostate Cancer?
9. Prognosis
The Gleason grade is a tool used to determine the prognosis of prostate cancer based on capsular penetration, margin positivity, and extent of tumor volume. High-grade prostate cancer (Gleason grades 4 and 5) is often associated with poor prognosis due to disease progression and pathologic findings. Low-grade prostate tumors are generally less dangerous.
Based on a review of 11,521 patients who have been treated with radical prostatectomy from 1987 to 2005, the reported mortality rate over 15 years was 7%. The Cancer of the Prostate Risk Assessment (CAPRA) score is also used to predict the prognosis based on the prostate specific antigen (PSA) levels, Gleason score, age at diagnosis, clinical tumor stage, and percentage of biopsy cores that are positive for cancer.
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