10 Side Effects of Antihistamines
Reviewed: Dr. Mera
Side Effect #1: Sedation or Drowsiness
Sedation refers to the reduction of agitation or irritability due to the administration of drugs. In this case, antihistamines can cause sedation which translates to drowsiness. Drowsiness or somnolence refers to the strong desire to sleep, which can also be caused by circadian rhythm disorders and illness.
Drowsiness can be dangerous, especially during daily activities such as driving. When fatigued, the individual may experience microsleeps. Sedation or drowsiness is a common side effect seen in H1 antihistamines that cross the blood brain barrier. Examples include doxylamine and diphenhydramine.
