10 Pyelonephritis Symptoms
Reviewed: Dr. Mera
Symptom #8: Loss of Appetite
Loss of appetite or anorexia is believed to be part of the acute phase response when there is an infection. It is thought to be triggered by peptidoglycans and lipopolysaccharides from bacterial cell walls, DNA, viral DNA, and viral glycoproteins.
The release of proinflammatory cytokines enhances the production of leptin which suppresses appetite. Appetite loss is seen in pneumonia, viral hepatitis, anxiety, cancer, chronic kidney disease, heart failure, dehydration, dementia, fever, hypothyroidism, and more. Appetite loss usually leads to weight loss.
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