What Is Systemic Scleroderma?
6. Is This Condition Genetic?
Systemic scleroderma is not identified as a genetic disorder, with limited to no evidence suggesting a familial connection. However, there is a link between other autoimmune diseases like rheumatoid arthritis, lupus and thyroid disease, which indicates that there may be a hereditary component that is currently unknown.
While there may not be a definitive genetic link to a family history of the disorder, scientists have identified several genes that could point to the risk of developing the disease. The genes in question come from a group of genes known as the human leukocyte antigen complex. The HLA complex aids the immune system in distinguishing between the body’s natural proteins and proteins made by a virus, bacteria or other foreign invaders. When these genes mutate or form a variation not in line with the body’s normal functioning, then an individual could end up with an autoimmune disorder.
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