What Is Motor Neuron Disease?
6. Hereditary Spastic Paraparesis
Hereditary spastic paraparesis (HSP) is also known as Strumpell-Lorrain disease or familial spastic paraplegias. This consists of a group of clinically and genetically heterogenous disorders characterized by slow and progressive spastic paraparesis.
HSP can be classified as a complicated or uncomplicated (pure) form. This will depend on if the paraparesis occurs by itself or in conjunction with other symptoms. Genetically, HSP can be classified based on the pattern of inheritance: X-linked, autosomal dominant, or autosomal recessive. The most common form of HSP is the pure autosomal dominant form. Individuals with HSP generally experience muscle weakness, abnormal gait, difficulty walking, paresthesia, and decreased sensation of vibrations.
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