What Is Fragile X?
8. Memory and Fertility
In fragile X syndrome, male patients beginning at the age of 40 will progressively develop issues with their working memory, which involves the temporary storage while processing other information. In terms of fertility, approximately 20% of women who are fragile X premutation carriers are affected by fragile X-related primary ovarian insufficiency (FXPOI), which can be defined as having menopause before the age of 40.
This is generally seen in females who are premutation carriers instead of the full mutation. Although they may develop menopause-like symptoms, these individuals can potentially get pregnant as their ovaries may still occasionally release eggs that are viable. FXPOI is one of the issues caused by changes in the FMR1 gene.
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