What Is Fragile X Syndrome?
5. Associated Conditions
A less severe mutation of the FMR1 gene causes fragile X-associated tremor/ataxia syndrome (FXTAS). Sometimes children with this genetic problem experience learning disabilities, but most people do not realize they have it until age 50, when symptoms begin and then worsen over time. People experience hand tremors, problems with balance, and memory impairment.
Fragile X-associated primary ovarian insufficiency (FXPOI) describes another suite of symptoms associated with the lesser FMR1 mutation. The symptoms only affect women and include decreased fertility, hot flashes, and early menopause. However, women with FXPOI still release eggs and therefore may still become pregnant or have periods after not menstruating for several years.
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