What Causes Moles?
3. Mechanism
Melanocytes are melanin-producing cells that can be found in the basal layer of the skin (epidermis). Melanocytes usually exhibit contact inhibition and therefore pigment cells are generally not touching. However, some forms of stimulation, such as exposure to ultraviolet irradiation (sun), may increase the density of melanocytes in the skin.
Moles develop when the melanocytes that are in contact with each other proliferate and form collections of cells that are also known as nests. Moles usually form in the early childhood years. It is believed to be partly due to ultraviolet (sun) exposure, genetic factors, and blistering events.
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