10 Sickle Cell Anemia Symptoms
Symptom #2: Fatigue
Fatigue is a sensation of tiredness that encompasses a range of complaints including malaise, lethargy, lassitude, and exhaustion. It is a nonspecific symptom; thus it can be observed in many conditions.
In sickle cell disease, the RBCs rupture easily either in the interior of blood vessels (intravascular hemolysis) or in organs of the reticuloendothelial system, such as the spleen (extravascular hemolysis). This results in anemia, where there is a decrease in the mass of red blood cells that can carry the oxygen supply for all the tissues in the body. A common symptom of anemia is fatigue.
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