What Is Peyronie's Disease?

2. Etiology

The cause of Peyronie’s disease is still unclear. It has been associated with the elevation of serotonin levels, vitamin E deficiency, ingestion of beta-blocking agents, Dupuytren contractures, HLA-B7 (genes), vascular trauma, penile injury, and more. An injury can trigger the release of cytokines activating the proliferation of fibroblasts and production of collagen. Based on an analysis on sociodemographic factors, it was identified that the potential risk factors also include diabetes mellitus, hypertension, systemic vascular diseases, hyperlipidemia, alcohol consumption, smoking, history of nongonococcal urethritis, and the use of propranolol. However, how these risk factors contribute to the condition is still unclear.

What Is Peyronie's Disease?

Home | Privacy Policy | Editorial | About Us

This site offers information designed for entertainment & educational purposes only. With any health related topic discussed on this site you should not rely on any information on this site as a substitute for professional medical diagnosis, treatment, advice, or as a substitute for, professional counseling care, advice, treatment, or diagnosis. If you have any questions or concerns about your health, you should always consult with a physician or other health-care professional.