What Is Peyronie's Disease?
2. Etiology
The cause of Peyronie’s disease is still unclear. It has been associated with the elevation of serotonin levels, vitamin E deficiency, ingestion of beta-blocking agents, Dupuytren contractures, HLA-B7 (genes), vascular trauma, penile injury, and more.
An injury can trigger the release of cytokines activating the proliferation of fibroblasts and production of collagen. Based on an analysis on sociodemographic factors, it was identified that the potential risk factors also include diabetes mellitus, hypertension, systemic vascular diseases, hyperlipidemia, alcohol consumption, smoking, history of nongonococcal urethritis, and the use of propranolol. However, how these risk factors contribute to the condition is still unclear.
Advertisement